PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate
![tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056318.gif "Click to View tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056318CAS No.: 1363381-93-4
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4-((tert-Butyldimethylsilyl)oxy)butan-1-ol
0 ImagesCat. No.: HY-W012471CAS No.: 87184-99-4
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1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid
0 ImagesCat. No.: HY-W001386CAS No.: 1303972-81-7
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tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride
![tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-30747.gif "Click to View tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-30747CAS No.: 1023301-84-9
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2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid
![2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid](https://file.medchemexpress.com/product_pic/hy-w108133.gif "Click to View 2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid Product Detail")
0 ImagesCat. No.: HY-W108133CAS No.: 120289-22-7
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Non-8-yn-1-ol
0 ImagesCat. No.: HY-W018054CAS No.: 10160-28-8Synonyms: 8-Nonyn-1-ol
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tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W004998CAS No.: 208167-83-3
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7-Octynylamine (7CI,8CI)
0 ImagesSynonyms: 7-Octyn-1-amine
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Propargyl-PEG2-OH
0 ImagesPropargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Propargyl-PEG2-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Amino-PEG2-(CH2)3COOH
0 ImagesCat. No.: HY-140190CAS No.: 1263046-77-0
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Biotin-PFP ester
0 ImagesCat. No.: HY-119343CAS No.: 120550-35-8
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Boc-NH-PEG5-CH2CH2COOH
0 ImagesCat. No.: HY-W022232CAS No.: 1347750-78-0
